A good inflammation resolution is associated with a correct healing and tissue repair. Ambiotis has recently developed new approaches in the area of healing, remodeling and regeneration. Our scratch assay allows the accurate evaluation of compound capacity to accelerate healing. It can be combined with biochemical analysis of lipids or cytokines. Our model of fibroblasts in co-culture with macrophages is perfectly suitable to observe the impact of compounds on the switch from pro-inflammatory to regenerative macrophages, the production of lipids involved in healing process (MCTR) and the remodeling of the extracellular matrix.