Analytical services validated on FDA guidelines dedicated to inflammatory and resolutive, diet-derived and skin lipids
Ambiotis proposes comprehensive and quantitative lipid analysis services for biological samples from any origins (preclinical or clinical studies) to pharmaceutical and biotech companies, nutraceutical and cosmetic industries but also to academic groups.
Applications
- Monitoring of biomarkers in preclinical / clinical studies
- Translational studies (from bed-to-benchside and inversely)
- Stratification approaches:
- Identification of biomarker to stratify patients and treatment response
- Identification of biomarker for disease monitoring
Cross-analysis of RNA, lipids, cytokines and chemokines can also be proposed.
Lipidomic analysis and monitoring of biomarkers
Quality
Ambiotis has developed robust analytical methods, in accordance with the appropriate standards (FDA guidelines) used during clinical trials
Internal standards are added to samples to follow the whole process.
Quantification
Absolute quantification is achieved using internal and external standards that allow accurate and direct quantitation of each metabolite.
Throughput
Up to 100 samples per day
List of mediators
- Eicosanoides
- Prostaglandins, tromboxanes, leukotriens
- SPMs : lipoxins, protectins, resolvins, maresins and theirs precursors
- Endocannabinoids (AEA, 2-AG, DHEA, EPEA)
- Fatty acids (saturated, mono/poly-unsaturated…) : DHA, EPA, ARA, omega-3 index, sapienic acid, sebaleic acid…
- Cholesterol, sterols, triglycerides
- Skin and sebum lipids :
- Squalene,
- Sapienic acid, sebaleic acid
- Cholesterol, sterols, triglycerides,
- Phospholipids, ceramides
Any kind of samples and matrices
- Cell supernatants
- Whole Tissue (intestine, lung, muscle, brain...)
- Serum
- Plasma
- BAL / CSF fluids
- Urine
- Oils
- Sebum
- Skin strips, corneodiscs
- Skin blisters
- Skin explants
- Biopsies
- On demand matrices